Exercise-induced arterial hypoxemia in aerobic and anaerobic trained athletes during incremental exercise

Keywords: desaturation in athletes, oxyhemoglobin saturation, pulse oximetry, cross-country skiers


Purpose: The purpose of this study was to examine and compare the occurrence of exercise-induced arterial hypoxemia (EIAH) in aerobic and anaerobic trained athletes during an incremental treadmill exercise test. Material: International level male junior skiers including ten cross-country skiers and ten alpine skiers took part in the study. All participants performed an incremental treadmill exercise test to determine maximal oxygen uptake (VO2max), and oxyhemoglobin saturation (SaO2) was continuously measured using a pulse oximetry. Maximal minute ventilation (VEmax), maximal heart rate (HRmax), ventilatory equivalent for oxygen (VE/VO2) and carbon dioxide (VE/VCO2) were determined during the last stage of the incremental exercise test. EIAH was assumed to have developed when SaO2 decreased by at least 4% (ΔSaO2 ≤ −4%) from the baseline values. Results: VO2max, VE, maximal running speed and test time were higher in the cross-country skiers than in the alpine skiers (p < 0.01), whereas HRmax, VE/VO2 and VE/VCO2 showed similar values in both group (p > 0.05). All the athletes in both groups exhibited EIAH. SaO2 was significantly decreased from 97.5 ± 0.9% at rest to 89 ± 2% at exhaustion in alpine skiers and from 97.8 ± 0.7% at rest to 88.1 ± 2.4% at exhaustion in cross-country skiers (p < 0.001). There were no differences in resting and lowest %SaO2 values between two groups (p > 0.05). Conclusions: EIAH may occur in endurance athletes as well as anaerobic trained athletes. Well-trained athletes who have different aerobic fitness levels may exhibit similar EIAH during the incremental maximal exercise.


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Author Biographies

Korkmaz Eryılmaz Selcen, School of Physical Education and Sports, Cukurova University
selcen_korkmaz@yahoo.com; 01330 Balcali, Saricam. Adana. Turkey
Polat Metin, School of Physical Education and Sports, Erciyes University
polat.metin@gmail.com; Erciyes University T Block, Kayseri, Turkey


Rowell LB, Taylor HL, Wang Y, Carlson WS. Saturation of arterial blood with oxygen during maximal exercise. Journal of applied physiology. 1964;19:284–286.

Dempsey JA, Wagner PD. Exercise induced arterial hypoxemia. Journal of applied physiology. 1999;87:1997–2006.

Dempsey JA, Hanson PG, Henderson KS. Exercise-induced arterial hypoxaemia in healthy human subjects at sea level. Journal of physiology. 1984;355:161–175.

Powers SK, Dodd S, Lawler J, Landry G, Kirtley M, McKnight T, Grinton S. Incidence of exercise induced hypoxemia in elite endurance athletes at sea level. European journal of applied physiology. 1988;58:298–302.

Guenette JA, Sheel AW. Exercise-induced arterial hypoxaemia in active young women. Applied physiology, nutrition, and metabolism. 2007;32(6):1263–73.

Powers SK, Lawler J, Dempsey JA, Dodd S, Landry G. Effects of incomplete pulmonary gas exchange on VO2max. Journal of applied physiology. 1989;66(6):2491–5.

Romer LM, Haverkamp HC, Lovering AT, Pegelow DF, Dempsey JA. Effect of exercise-induced arterial hypoxemia on quadriceps muscle fatigue in healthy humans. American journal of physiology. Regulatory, integrative and comparative physiology. 2006;290:R365–R375.

Williams JH, Powers SK, Stuart MK. Hemoglobin desaturation in highly trained athletes during heavy exercise. Medicine and science in sports and exercise. 1986;18:168–73.

Harms CA, McClaran SR, Nickele GA, Pegelow DF, Nelson WB, Dempsey JA. Effect of exercise-induced arterial O2 desaturation on VO2max in women. Medicine and science in sports and exercise. 2000;32(6):1101–8.

Hopkins SR, McKenzie DC, Schoene RB, Glenny RW and H. T. Robertson. Pulmonary gas exchange during exercise in athletes. I. Ventilation-perfusion mismatch and diffusion limitation. Journal of applied physiology. 1994;77: 912–917.

Prefaut C, Durand F, Mucci P, Caillaud C. Exercise-induced arterial hypoxaemia in athletes: a review. Sports medicine. 2000;30:47–61.

Alis R, Sanchis-Gomar F, Ferioli D, La Torre A, Blesa JR, Romagnoli M. Exercise Effects on Erythrocyte Deformability in Exercise-induced Arterial Hypoxemia. International Journal of Sports Medicine. 2015;36(4):286–91.

Gaston AF, Durand F, Roca E, Doucende G, Hapkova I, Subirats E. Exercise-induced hypoxaemia developed at sea-level influences responses to exercise at moderate altitude. PLOS ONE. 2016;11(9):e0161819.

Amann M, Romer LM, Subudhi AW, Pegelow DF, Dempsey JA. Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans. Journal of physiology. 2007;581(1):389–403.

Grataloup O, Busso T, Castells J, Denis C, Benoit H. Evidence of decrease in peak heart rate in acute hypoxia: effect of exercise-induced arterial hypoxemia. International Journal of Sports Medicine. 2007;28:181–185.

Galy O, Le Gallais D, Hue O, Boussana A, Prefaut C. Is Exercise-induced arterial hypoxemia in triathletes dependent on exercise modality?. Internation Journal of Sports Medicine, 2005; 26(9):719–726.

Vogiatzis I, Georgiadou O, Giannopoulou I, Koskolou M, Zakynthinos S, Kostikas K, Kosmas E, Wagner H, Peraki E, Koutsoukou A, Koulouris N, Wagner PD, Roussos C. Effects of exercise-induced arterial hypoxaemia and work rate on diaphragmatic fatigue in highly trained endurance athletes. Journal of physiology. 2006; 572(2):539–549.

Rice AJ, Scroop GC, Gore CJ, Thornton AT, Chapman MJ, Greville HW, Holmes MD, Scicchitano R. Exercise-induced hypoxaemia in highly trained cyclists at 40% peak oxygen uptake. European journal of applied physiology. 1999;79:353–359.

Thalheimer W, Cook S. How to calculate effect sizes from published research articles: A simplified methodology. 2002. [cited 2016 January 11]. Available from: http://work learning.com/effect_sizes.htm.

Miyachi M, Katayama K: Effects of maximal interval training on arterial oxygen desaturation and ventilation during heavy exercise. Japanese journal of physiology, 1999;49:401–407.

White AT, Johnson SC. Physiological comparison of international, national and regional alpine skiers. International Journal of Sports Medicine. 1991;12(4):374–378.

Hydren JR, Volek JS, Maresh CM, Comstock BA, Kraemer WJ. Review of strength and conditioning for alpine ski racing. Strength & Conditioning Journal. 2013;35:10–28.

Bosco C, Cotelli F, Bonomi R, Mognoni P, Roi GS. Seasonal fluctuations of selected physiological characteristics of elite alpine skiers. European journal of applied physiology and occupational physiology.1994;69:71–74.

Staib JL, Im J, Caldwell Z, Rundell KW. Cross-country ski racing performance predicted by aerobic and anaerobic double poling power. Journal of strength and conditioning research. 2000;14(3):282–288.

Holmberg HC. The elite cross-country skier provides unique insights into human exercise physiology. Scandinavian Journal of Medicine & Science in Sports. 2015;25(4):100–109.

Sandbakk Ø, Holmberg HC. A reappraisal of success factors for olympic cross-country skiing. International journal of sports physiology and performance. 2014;9(1):117–21.

Martin D, Powers S, Cicale M, Collop N, Huang D, Criswell D. Validity of pulse oximetry during exercise in elite endurance athletes. Journal of applied physiology. 1992; 72: 455–458.

Powers SK, Dodd S, Freeman J, Ayers GD, Samson H, Mcknight T. Accuracy of pulse oximetry to estimate HbO2 fraction of total Hb during exercise. Journal of applied physiology. 1989;67:300–304.

Mollard P, Bourdillon N, Letournel M, Herman H, Gibert S, Pichon A, et al. Validity of arterialized earlobe blood gases at rest and exercise in normoxia and hypoxia. Respiratory Physiology Neurobiology. 2010; 172: 179–183.

Brown DD, Knowlton RG, Sanjabi PB, Szurgot BT. Re-examination of the incidence of exercise-induced hypoxaemia in highly trained subjects. British Journal Sports Medicine. 1993; 27(3):167-70.

Powers SK, Dodd S, Woodyard J, Beadle RE, Church G. Haemoglobin saturation during incremental arm and leg exercise. British Journal Sports Medicine. 1984; 18: 212-16.

Rasmussen J, Hanel B, Diamant B, Secher NH. Muscle mass effect on arterial desaturation after maximal exercise. Medicine and science in sports and exercise. 1991;23:1349–1352.

Rice AJ, Scroop GC, Thornton AT, McNaughton NS, Rogers KJ, Chapman MJ, Greville HW, Scicchitano R, Gore CJ. Arterial hypoxaemia in endurance athletes is greater during running than cycling. Respiratory Physiology. 2000:123: 235–246.
How to Cite
Selcen KE, Metin P. Exercise-induced arterial hypoxemia in aerobic and anaerobic trained athletes during incremental exercise. Physical education of students. 2018;22(2):99-03. https://doi.org/10.15561/20755279.2018.0207

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